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Acemetacin 60
- Pain and inflammation are associated with musculoskeletal and joint disorders, including rheumatoid arthritis, osteoarthritis, and low back pain.
- Pain after an operation.
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✅ Description:
Acemetacin is indicated for the treatment of various conditions including low back pain, osteoarthritis, postoperative inflammation, postoperative pain, and rheumatoid arthritis.
Acemetacin should be taken with food, preferably with or immediately after meals.
Monitoring parameters include blood pressure, complete blood count with differential during prolonged use, renal function tests, liver function tests, and observation for gastrointestinal effects and bleeding. Ophthalmologic exams may also be necessary during prolonged use.
In case of an overdose, symptomatic treatment is recommended. Measures such as administration of activated charcoal or gastric lavage within 1 hour of ingestion may be considered. Renal and hepatic function should be closely monitored, and symptomatic relief should be provided as needed.
Acemetacin may interact with other medications, increasing the risk of adverse effects. It may also alter the metabolism or excretion of various drugs, including anticoagulants, diuretics, cardiac glycosides, phenytoin, lithium, methotrexate, and others.
Acemetacin is a glycolic acid ester of indomethacin. Its precise mechanism of action is not fully understood, but it is believed to exert its pharmacological activity through inhibition of prostaglandin synthesis. Unlike other NSAIDs, it is considered a weak inhibitor of prostaglandin synthetase.
Acemetacin is well absorbed from the gastrointestinal tract, with 100% bioavailability after 10 days of therapy. It reaches peak plasma concentration approximately 2.6 hours after immediate-release administration and 6 hours after extended-release administration. It is metabolized in the liver to its major metabolite, indometacin, and eliminated via feces and urine, with an elimination half-life of approximately 1.1-1.8 hours.
Patients with various medical conditions such as bronchial asthma, chronic respiratory disease, hypertension, heart failure, gastrointestinal disorders, psychiatric disorders, and others should use acemetacin with caution. Concomitant use with other NSAIDs should be avoided. Extended-release capsules are not recommended for initial relief of acute pain. Mild to moderate renal and hepatic impairment, as well as elderly or debilitated patients, require special consideration. Pregnancy (first and second trimester) and lactation are also precautionary situations.
✔️ Uses of Tendonil 60
Treatment of rheumatoid arthritis, osteoarthritis, and low back pain
✔️ How does Tendonil 60 work?
Acemetacin inhibits cyclooxygenase, preventing the formation of prostaglandins involved in the inflammation process.
✔️ Side Effects of Tendonil 60
- Common: anorexia, nausea, vomiting, diarrhea, constipation, peptic ulceration, headache, dizziness, vertigo.
- Rare: confusion, depressed mood, edema, chest pain, elevated blood urea.
✔️ Quick Suggestions:
- May reduce the antihypertensive effect of beta-blockers.
- May prolong bleeding when used with acenocoumarol.
- Increased risk of convulsion when used with quinolone.
- Concurrent use of aspirin, NSAIDs, SSRIs, or corticosteroids may increase the risk of GI bleeding.
- May increase serum levels of ciclosporin.
- May increase serum levels of lithium.
- Potentially fatal: Increased risk of methotrexate toxicity when used together.
✔️ Indications:
- Reduces the antihypertensive effect of beta-blockers.
- Increases the risk of convulsion when used with quinolones.
- Concurrent use of aspirin, NSAIDs, or corticosteroids may increase the risk of gastrointestinal bleeding.
- Increases the risk of methotrexate toxicity when used together.
✔️ Pharmacology
Acemetacin, the active ingredient in Tendonil, is a non-steroidal anti-inflammatory drug (NSAID) that works by blocking cyclooxygenase (COX), which is involved in producing irritant chemicals in response to injury or rheumatic disease. By blocking COX, acemetacin reduces pain and inflammation symptoms.
✔️ Dosage & Administration:
- Recommended starting dose: 120mg/day in divided doses, increasing to 180mg/day in divided doses based on patient response.
- Adjustment of dosage is generally not required for elderly patients, but NSAIDs should be used with caution due to the increased risk of adverse reactions.
- Acemetacin should be taken with food, milk, or an antacid to reduce the possibility of gastrointestinal disturbance.
✔️ Interaction
- Reduces the antihypertensive effect of beta-blockers.
- Increases the risk of convulsion when used with quinolones.
- Concurrent use of aspirin, NSAIDs, or corticosteroids may increase the risk of gastrointestinal bleeding.
- Increases the risk of methotrexate toxicity when used together.
✔️ Contraindications
- Known hypersensitivity to acemetacin or indomethacin.
- Peptic ulcer.
- Safety in children is not established.
✔️ Pregnancy & Lactation
- Safety during human pregnancy and lactation is not established.
- Animal reproduction studies have shown some toxic/teratogenic effects on the fetus, so use during pregnancy and lactation is not recommended.
✔️ Precaution & Warnings:
Caution should be exercised in elderly individuals, those with a history of stomach or intestinal disorders, inflammatory bowel disease, kidney disease, liver disease, or heart failure.
✔️ Storage Conditions:
Store in a cool, dry place below 25℃, and away from light.
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